Species: Human Expressing host: E. coli Description: Active Recombinant Human Pro-neuregulin-1/NRG1 Protein is produced byE. coliexpression system. The target protein is expressed with sequence (Ser177-Lys241) of human NRG1-alpha/HRG1-alpha (Accession #NP_039258.1). Tag: No tag Purity: > 95% by SDS-PAGE. Endotoxin: Biological Activity: Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED50for this effect is typically 6.2-24.7 ng/mL, corresponding to a specific activity of 4.0104-1.61105units/mg. preparation: Lyophilized from a 0.22 m filtered solution of 20mM Tris, 150mM NaCl, 5% glycerol, pH 8.0.Contact us for customized product form or formulation. Storage Store the lyophilized protein at -20C to -80 C for long term.
After reconstitution, the protein solution is stable at -20 C for 3 months, at 2-8 C for up to 1 week.Unopened freeze-dried powder,Store at -20 to -80 °C for twelve months
Redissolution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.Redissolution:Store at -20 to -80 °C,avoid repeated freeze thaw cycles
Background Information : The protein is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. GeneID 3084 Swiss Prot Q02297 Alias: NRG1;ARIA;GGF;GGF2;HGL;HRG;HRG1;HRGA;MST131;MSTP131;NDF;NRG1-IT2;SMDFMedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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