Rs microglial activation and reduces beta-amyloid deposition in two Alzheimer’s disease mouse models. Am J Pathol 2010, 177:2549562. Desforges NM, Hebron ML, Algarzae NK, Lonskaya I, Moussa CE: Fractalkine mediates communication amongst pathogenic proteins and microglia: implications of anti-inflammatory therapies in unique stages of neurodegenerative ailments. Int J Alzheimers Dis 2012, 201(two):345472. Madrigal JL, Dello RC, Gavrilyuk V, Feinstein DL: Effects of noradrenaline on neuronal NOS2 expression and viability. Antioxid Redox Signal 2006, 8:88592. Cerbai F, Lana D, Nosi D, Petkova-Kirova P, Zecchi S, Brothers HM, Wenk GL, Giovannini MG: The neuron-astrocyte-microglia triad in regular brain ageing and inside a model of neuroinflammation in the rat hippocampus. PLoS One particular 2012, 7:e45250. Zlotnik A, Yoshie O: Chemokines: a brand new classification technique and their part in immunity. Immunity 2000, 12:12127. Rosito M, Deflorio C, Limatola C, Trettel F: CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to guard neurons from excitotoxic cell death in the CNS. J Neurosci 2012, 32:3154163. Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, Gahring LC: Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin by way of distinct pathways. J Immunol 1999, 163:3963968. Figiel I: Pro-inflammatory cytokine TNF-alpha as a neuroprotective agent within the brain. Acta Neurobiol Exp (Wars) 2008, 68:52634.Hinojosa et al. Journal of Neuroinflammation 2013, 10:81 http://www.jneuroinflammation/content/10/1/Page 10 of26. Shaftel SS, Griffin WS, O’Banion MK: The function of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving point of view.SMCC J Neuroinflammation 2008, 5:7. 27. Dello RC, Boullerne AI, Gavrilyuk V, Feinstein DL: Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production.VV116 J Neuroinflammation 2004, 1:9.PMID:34816786 28. Re DB, Przedborski S: Fractalkine: moving from chemotaxis to neuroprotection. Nat Neurosci 2006, 9:85961. 29. Kalinin S, Polak PE, Lin SX, Sakharkar AJ, Pandey SC, Feinstein DL: The noradrenaline precursor L-DOPS reduces pathology inside a mouse model of Alzheimer’s illness. Neurobiol Aging 2012, 33:1651663. 30. Traver S, Salthun-Lassalle B, Marien M, Hirsch EC, Colpaert F, Michel PP: The neurotransmitter noradrenaline rescues septal cholinergic neurons in culture from degeneration brought on by low-level oxidative strain. Mol Pharmacol 2005, 67:1882891. 31. Madrigal JL, Feinstein DL, Dello RC: Norepinephrine protects cortical neurons against microglial-induced cell death. J Neurosci Res 2005, 81:39096. 32. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ: A brand new class of membrane-bound chemokine using a CX3C motif. Nature 1997, 385:64044. 33. Bruno V, Copani A, Besong G, Scoto G, Nicoletti F: Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture. Eur J Pharmacol 2000, 399:11721. 34. Elhofy A, Wang J, Tani M, Fife BT, Kennedy KJ, Bennett J, Huang D, Ransohoff RM, Karpus WJ: Transgenic expression of CCL2 within the central nervous program prevents experimental autoimmune encephalomyelitis. J Leukoc Biol 2005, 77:22937. 35. Eugenin EA, D’Aversa TG, Lopez L, Calderon TM, Berman JW: MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem 2003, 85:1299311. 36. Godefroy D, Gosselin RD, Yasut.