Weiss LM. Chronic lymphocytic leukemia/small lymphocytic lymphoma with Reed-Sternberg-like cells and doable transformation to Hodgkin’s illness. Mediation by Epstein-Barr virus. Am J Surg Pathol. 1992; 16:85967. [PubMed: 1384376] 36. Mao Z, Quintanilla-Martinez L, Raffeld M, et al. IgVH mutational status and clonality analysis of Richter’s transformation: diffuse significant B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 various pathways of illness evolution. Am J Surg Pathol. 2007; 31:1605614. [PubMed: 17895764] 37. Tzankov A, Bourgau C, Kaiser A, et al. Rare expression of T-cell markers in classical Hodgkin’s lymphoma. Mod Pathol. 2005; 18:1542549. [PubMed: 16056244] 38. Asano N, Oshiro A, Matsuo K, et al. Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin’s lymphoma: a clinicopathologic study. J Clin Oncol. 2006; 24:4626633. [PubMed: 16954517] 39. Takahashi T, Maruyama R, Mishima S, et al. Little bowel perforation triggered by Epstein-Barr virus-associated B cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma. J Clin Exp Hematop. 2010; 50:593. [PubMed: 20505277]NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptAm J Surg Pathol.Mogamulizumab Author manuscript; offered in PMC 2014 June 01.Cabotegravir Nicolae et al.PageNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptFigure 1.PMID:24118276 Angioimmunoblastic T-cell lymphoma with EBV-positive Hodgkin-Reed Sternberg-like cells. A. A big multinucleate cell is observed in a background of atypical lymphoid cells. B. CD3 highlights the cytologic atypia within the T-cells and presence of rosettes about HodgkinReed Sternberg-like cell (upper left corner). C. T-cell rosettes are positive for CD10. D. Expanded CD21-positive follicular dendritic meshworks surround multinucleated cells (upper left corner). The Hodgkin-Reed Sternberg-like cells show strong membrane positivity for CD30 (E), CD15 (F), weak nuclear staining for PAX5 (G) and EBER positivity (H).Am J Surg Pathol. Author manuscript; readily available in PMC 2014 June 01.Nicolae et al.PageNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptFigure 2.Angioimmunoblastic T-cell lymphoma with EBV-negative Hodgkin-Reed Sternberg-like cells (circumstances 1 and two). A. Effaced lymph node with paracortical expansion and preserved and dilated peripheral cortical sinus. B. Polymorphous infiltrate composed of pleomorphic cells with uni or multilobated nuclei and prominent nucleoli, resembling Hodgkin-Reed Sternberg cells admixed with medium sized atypical lymphocytes. C. Dilated subcapsular sinus with atypical Hodgkin-Reed Sternberg-like cells (detail in inset) D. Hodgkin-Reed Sternberg-like cells (detail in inset) are embedded in expanded CD21-positive follicular dendritic cell meshworks. They may be positive for CD30 (E), CD15 (F), variably optimistic for CD20 (G inset), weakly positive for PAX5 (H), but adverse for EBER (I). G. CD20 stain shows alsoAm J Surg Pathol. Author manuscript; readily available in PMC 2014 June 01.Nicolae et al.Pagemarginalized B-cell regions inside the far cortex. The Hodgkin-Reed Sternberg-like cells are rosetted by neoplastic T-cells constructive for CD3 (J), PD-1 (K), CD10 (L). M. HRS-cells are damaging for Bcl-6, which stains some background T-cells. (A, B, C, F, G, H, K, L M case 1; D, E I, J ase 2)NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptAm J Surg Pathol. Author manuscript; availabl.