Avonoid drugs for the Benzyl selenocyanate Biological Activity pharmaceutical chemists. All these findings were extraordinary helpful for us to explore the potential structure-inhibition relationships about flavonoids as UGT1A1 inhibitors, which was also quite useful to designing and creating far more potent TBCA manufacturer flavonoid-type inhibitors against UGT1A1 for the pharmaceutical chemists, also as for the improvement of novel flavonoid drugs with improved safety profiles. Keywords and phrases: Flavonoids; UGT1A1; Structure nhibition partnership; High-throughput screening.References 1. Xin in Wang, GuangBo Ge, et al. Toxicol Appl Pharmacol. 2015;289:70?. two. Xia Lv, Xin in Wang et al. Toxicol Appl Pharmacol. 2016;301:42?. 3. Xia Lv, GuangBo Ge, et al. Biosens Bioelectr. 2015;72:261?.71 Impact of Debaryomyces hansenii therapy on intestinal microorganism in mice with antibioticinduced diarrhea Lu He1, Chengxing Long1,two, Youjia Liu1, Yanfang Guo1, Nenqun Xiao1, Zhoujin Tan1 1 Hunan University of Chinese Medicine, Changsha, Hunan Province, China; 2Hunan University of Humanities Science and Technology, LouDi, Hunan Province, China Correspondence: Zhoujin Tan [email protected]; Nenqun Xiao [email protected]; [email protected] Journal of Chinese Medicine 2018, 13(Suppl 1):71 Background: Debaryomyces hansenii, which was isolated from food or intestinal contents of experimental mice, was identified as a halotolerant yeast using a higher biotechnological prospective, particularly in food industry. It has been demonstrated that Debaryomyces hansenii adjusts the microecosystem balance and has curative effect on antibiotic-induced diarrhea. Our objective was to investigate the influence of Debaryomyces hansenii treatment on intestinal microorganisms of mice with symptom of antibiotics-induced diarrhea. Components and methods: Eighteen particular pathogen cost-free (SPF) mice were randomly selected into three groups: healthy control group, diarrhea control group and diarrhea treated group. Mice model with antibiotic-induced diarrhea was constructed by gavaging mixed antibiotics (23.33 mL kg-1 day-1) composed of gentamycin sulfate and cefradine for five days. After the accomplishment of modeling, mice have been treated with D. hansenii by intragastric administration. In the control group, mice had been given steriled water. Four days right after therapy, total DNA of intestinal microflora of treated and control mice was extracted, andChin Med 2018, 13(Suppl 1):Page 35 oftheir quantities were measured by sequencing the V4 region of 16S rDNA. Final results: When compared with all the handle, therapy with D. hansenii enhanced the operational taxonomic units (OTUs) of intestinal bacteria. The density and diversity of intestinal bacterial population have been recovered in treated mice. Although, there was no important impact on theirs at genus level. Interestingly, the therapy recovered the population density of certain bacterium species, like Bacteroidaceae (in family level). Conclusion: Our outcomes indicate that the ecosystem of intestinal bacteria is adaptable and adjustable with therapy of D. hansenii. Acknowledgements: This operate was supported by grants in the National Organic Science Foundation of China (No. 81573951). 72 MYC2 have a vital part in biosynthesis of active compounds in Salvia miltiorrhiza Bunge Wenzhi Cao, Fenfen Huang, Min Shi, Yao Wang and Guoyin Kai Institute of Plant Biotechnology, College of Life and Environment Sciences, Shanghai Regular University, Shanghai 200234, China Correspondence: Guoyin Kai [email protected] Journa.