S with BMI 25 (50.8 with the population) have been generally stronger than those for BMI 25. Among participants using a BMI 25, the associations involving rs11642841 inside the FTO gene (i.e., the only SNP reaching GWAS significance in Hwang et al. [16]) and total sugar, added sugar, and sweet sugars, too as sucrose intake were strengthened in comparison to the main final results. Indications of interactions among BMI and rs11642841 on total sugar, added sugar, and sugars with sweet taste had been identified (p = 0.04 for all outcomes). For BMI 25, only a number of associations met the Bonferroni-corrected threshold of significance, including the Goralatide MedChemExpress association of rs838133 with an intake of sugars with a sweet taste and rs60764613 with cake intake (Figure 3, Tables S6 and S7). In additional sensitivity analyses, we observed that the exclusion of present smokers strengthened the associations from the 3 SNPs inside or close to the FGF21 gene (rs838145, rs838133 and rs8103840) with total sugar. The associations among rs60764613 and total sugar and sugars using a sweet taste had been also strengthened, reaching a significance of p 0.05 but not reaching the Bonferroni-corrected threshold of significance (Figure S1,Nutrients 2021, 13,of significance, such as the association of rs838133 with an intake of sugars using a sweet taste and rs60764613 with cake intake (Figure three, Tables S6 and S7). In further sensitivity analyses, we observed that the exclusion of existing smokers strengthened the associations with the 3 SNPs inside or close to the FGF21 gene (rs838145, of 14 rs838133 and rs8103840) with total sugar. The associations amongst rs60764613 and 9total sugar and sugars having a sweet taste had been also strengthened, reaching a significance of p 0.05 but not reaching the Bonferroni-corrected threshold of significance (Figure S1, Table S8). When potential power misreporters and diet changers were excluded (34.five Table S8). When potential power misreporters and diet plan changers had been excluded (34.five on the population), a enuations of a number of associations had been observed whereas a number of the population), attenuations of some associations were observed whereas some assoassociations had been strengthened. For instance, rs8103840 (FUT1 and FGF21 genes) ciations were strengthened. For instance, rs8103840 (FUT1 and FGF21 genes) association association with total sugar intake was a enuated but remained considerably with total sugar intake was attenuated but remained considerably Bonferroni-corrected Bonferroni-corrected (p 0.005), along with the associations of rs838145 (FGF21 gene) and (p 0.005), and the associations of rs838145 (FGF21 gene) and rs60764613 (CTD-2015H3 rs60764613 (CTD-2015H3 gene) and added sugar intake were a enuated and no LY294002 supplier longer gene) and added sugar intake had been attenuated and no longer reached the Bonferronireached the Bonferroni-corrected associations among rs838133associations among corrected significance, whereas the significance, whereas the (FGF21 gene) and the rs838133 (FGF21were strengthened. (Figure S2, were strengthened. (Figure S2, Table S9). key outcomes gene) and the principal outcomes Table S9).Figure 3. Sensitivity analyses studying participants with BMI 25 and 2525 separately. The figure shows results for the Figure three. Sensitivity analyses studying participants with BMI 25 and separately. The figure shows benefits for the ten key SNPs and all outcomes. The impact sizes are presented as /SEE. SEE: Common error on the estimate. 1 Sucrose ten main SNPs and all outcom.