Anocarriers for Hyperproliferative Skin Ailments. Cancers 2021, 13, 5619. https:// doi.org/10.3390/cancers13225619 Academic
Anocarriers for Hyperproliferative Skin Ailments. Cancers 2021, 13, 5619. https:// doi.org/10.3390/cancers13225619 Academic Editors: Maciej Wnuk and Anna Lewinska Received: 6 October 2021 Accepted: 5 November 2021 Published: ten NovemberCEB–Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal Faculty of Pharmaceutical Sciences, S Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Ja Araraquara 14800-903, SP, Brazil; [email protected] (A.L.R.d.S.); [email protected] (F.K.d.S.); [email protected] (M.P.D.G.); [email protected] (M.C.) Division of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain; [email protected] (E.S.-L.); [email protected] (A.C.) Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08007 Barcelona, Spain Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland; [email protected] Department of Hypertension Angiology and Internal Medicine, Poznan University of (Z)-Semaxanib c-Met/HGFR Healthcare Sciences, 61-701 Poznan, Poland; [email protected] Division of Environmental Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland Department of Gastroenterology, Dietetics and Internal Diseases, H. Swiecicki University Hospital, Poznan University of Healthcare Sciences, 60-355 Poznan, Poland Correspondence: [email protected] (E.B.S.); [email protected] (J.K.)Very simple Summary: Unique drugs, such as antiproliferative and corticosteroids generally, are encouraged for the therapy of hyperproliferative skin illnesses (HSD). The effectiveness of a lot of of these drugs is limited because of their low solubility in water and low penetration in the skin. The loading of these drugs in lipid nanocarriers, like lipid nanoparticles and liposomes, has been viewed as as a thriving option to enhance the drug bioavailability by way of the skin, to handle their release kinetics and thus decrease the risk of potential negative effects. Within this perform, we talk about the use of lipid nanocarriers loading drugs against HSD. Abstract: Hyperproliferative skin diseases (HSD) are a group of illnesses that include cancers, precancerous lesions and diseases of unknown etiology that present distinct skin manifestations when it comes to the degree and distribution of the injuries. Anti-proliferative agents utilized to treat these ailments are so diverse, like 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs typically have low aqueous solubility, which consequently decreases skin permeation. Hence, their incorporation in lipid nanocarriers has been proposed with the major objective to improve the effectiveness of topical remedy and reduce negative effects. This manuscript aims to describe the advantages of utilizing lipid nanoparticles and liposomes that can be employed to load diversity of chemically different drugs for the therapy of HSD. Key phrases: lipid nanoparticles; liposomes; hyperproliferative skin illnesses; antiproliferative drugs; skin cancerPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Hydroxyflutamide Purity & Documentation Switzerland. This short article is definitely an open access report distributed under the t.