Normal keratinocytes. The normal keratinocytes Figure 3. Alterations from the branch chain amino acid pathway in PPOL and standard keratinocytes. The standard keratinocytes are shown in green, the LR MPPOL keratinocytes in blue, the HR IPPOL keratinocytes in yellow (D4 and D9) and purple are shown in green, the LR MPPOL keratinocytes in blue, the HR IPPOL keratinocytes in yellow (D4 and D9) and purple (D19, D20 and D35), plus the LR PPOL p16INK4A -/- line D17 in brown.CDC Inhibitor manufacturer Information represents the signifies of 3 independent (D19, D20 and D35), and the LR PPOL p16INK4A -/- line D17 in brown. Data represents the indicates of experiments +/- standarddeviation. For statistical analyses see Supplementary Tables S3 7. BCAT = branched-chain +/- standard deviation. For statistical analyses see Supplementary Tables = branched-chain amino acid transaminase; BCKD = acid dehydrogenase complicated. amino acid transaminase; BCKD = Branched-chain alpha-keto acid dehydrogenase complicated.Cancers 2021, 13,13, x Cancers 2021, 4212 Cancers 2021, 13, x9 ten 22 10of of 25 ofFigure 4. Alterations of lipid metabolism in PPOL and normal keratinocytes. The symbols are the identical as for Figure 3. Data Figure 4. Alterations of lipid metabolism in PPOL and typical keratinocytes. The symbols will be the exact same as for Figure three. Figure four. Alterations of lipid metabolism in PPOL and normal keratinocytes. The symbols will be the very same as for Figure 3. represents the suggests means of 3 independent experiments +/- typical deviation. For statistical analyses see SuppleData represents the implies of 3 independent experiments +/- standard deviation. For statistical analyses see SuppleData represents the of three independent experiments +/- normal deviation. For statistical analyses see Supplementary Tables S3 7. TCAS3 7. TCA = tricarboxylic acid cycle. mentary Tables = tricarboxylic acid cycle. mentary Tables S3 7. TCA = tricarboxylic acid cycle.Figure 5. five. Alterations of Prostaglandin metabolism in PPOL and normal keratinocytes. The symbols will be the identical as for Figure Alterations of prostaglandin metabolism in PPOL and regular keratinocytes. The symbols will be the same as for Figure 5.Alterations of prostaglandin metabolism in PPOL and typical keratinocytes. The symbols would be the very same as for Figure 3. 3. Information represents the signifies three independent experiments +/- common deviation. For statistical analyses see Figure Information represents the suggests of 3 independent experiments +/- regular deviation. For statistical analyses see Figure 3.Data represents the implies of of 3 independent experiments +/- standard deviation. For statistical analyses see Supplementary Tables S3 7. COX cyclooxygenase; FADS fatty acid desaturase; PLA2 phospholipase A2; FA fatty Supplementary Tables S3 7. COX = cyclooxygenase; FADS = fatty acid desaturase; PLA2 = phospholipase A2; FA = fatty Supplementary Tables S3 7. COX ==cyclooxygenase; FADS ==fatty acid desaturase; PLA2 ==phospholipase A2; FA ==fatty acid; CYP8A HDAC Inhibitor Compound Cytochrome P450 8A; PTGDS = Prostaglandin D synthase; and PTGES = Prostaglandin E synthase. acid;CYP8A ==Cytochrome P450 8A; PTGDS = Prostaglandin D D synthase; and PTGES Prostaglandin E E synthase. acid; CYP8A = Cytochrome P450 8A; PTGDS = Prostaglandin synthase; and PTGES = = Prostaglandin synthase.Cancers 2021, 13, 4212 Cancers 2021, 13, x10 of 22 11 ofFigure 6. Alterations from the glutathione metabolism in PPOL and standard keratinocytes. The symbols are the same as for Figure 6. Alterations in the glutathione metabolism in P.