Purity: > 97 % as determined by SDS-PAGE Endotoxin: Please contact us for more information. Biological Activity: Yes Protein construction: A DNA sequence encoding the mouse IL1F6 (Q9JLA2-1) (Met 1-His 160) was expressed and purified. Uniprot No. Q9JLA2-1 Expressing host: E. coli Species: Mouse Met 1 Molecular Weight: The recombinant mouse IL1F6 consisting of 160 amino acids and migrates with an apparent molecular mass of 18 kDa as predicted. Buffer solution: Lyophilized from sterile PBS, pH 7.4
Pleasecontact usfor any concerns or special requirements.
Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. Transportation method: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. stability & Storage: Samples are stable for up to twelve months from date of receipt at -20 to -80. Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Redissolution: A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. IL36 alpha/IL-1F6 Protein, Mouse, Recombinant: Alternative name : FIL1 Protein, Mouse; FIL1(EPSILON) Protein, Mouse; FIL1E Protein, Mouse; IL-1F6 Protein, Mouse; IL1(EPSILON) Protein, Mouse; IL1F6 Protein, Mouse IL36 alpha/IL-1F6
Background Information : Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP. Full Name: interleukin 36, alphaMedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
Ezrin/EZR Protein
Thymidine kinase 1/TK1 Protein
Popular categories:
Vitamin D Receptor
C-Type Lectin Domain Family 10 Member A/CD301