Species: Human Expressing host: E. coli Description: Recombinant Human GDF-5/BMP-14 Protein is produced byE. coliexpression system. The target protein is expressed with sequence (Ala382-Arg501) of human GDF-5/BMP-14 (Accession #P43026) fused with an initial Met at the N-terminus. Tag: No tag Purity: > 95% by SDS-PAGE. Endotoxin: Biological Activity: Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50for this effect is 0.2-1.2 g/mL. preparation: Lyophilized from a 0.2 m filtered solution of 4 mM HCl.Contact us for customized product form or formulation. Storage Store the lyophilized protein at -20C to -80 C for long term.
After reconstitution, the protein solution is stable at -20 C for 3 months, at 2-8 C for up to 1 week.Unopened freeze-dried powder,Store at -20 to -80 °C for twelve months
Redissolution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.Redissolution:Store at -20 to -80 °C,avoid repeated freeze thaw cycles
Background Information : This protein belongs a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. GeneID 8200 Swiss Prot P43026 Alias: GDF5;BDA1C;BMP-14;BMP14;CDMP1;LAP-4;LAP4;OS5;SYM1B;SYNS2MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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