Species: Mouse Expressing host: HEK293 cells Description: Recombinant Mouse IL-1 R2/IL-1 RII Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Phe14-Glu355) of mouse IL-1 R2/IL-1 RII (Accession #P27931) fused with a 6His tag at the C-terminus. Tag: C-6His Purity: > 95% by SDS-PAGE. Endotoxin: preparation: Lyophilized from a 0.2 m filtered solution of PBS, pH7.4.Contact us for customized product form or formulation. Storage Store the lyophilized protein at -20C to -80 C for long term.
After reconstitution, the protein solution is stable at -20 C for 3 months, at 2-8 C for up to 1 week.Unopened freeze-dried powder,Store at -20 to -80 °C for twelve months
Redissolution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.Redissolution:Store at -20 to -80 °C,avoid repeated freeze thaw cycles
Background Information : Mouse Interleukin 1 receptor, type II (IL1R2) is a cytokine receptor that belongs to the interleukin-1 receptorfamily. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. IL-1R2 structurally consistingof a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a shortcytoplasmic domain. It is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes,large granular leukocytes and endothelial cells. Mouse IL1RII shares 59% amino acid sequence homology withhuman IL1 RII in their extracellular domains. The pleiotropic cytokine IL1 is produced to regulate developmentand maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells.Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated asIL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2 has no signalingproperty and acts as a decoy for IL-1. GeneID 16178 Swiss Prot P27931 Alias: Interleukin-1 receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B;CD121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor typeII; CD121bMedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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