Purity: > 95 % as determined by SDS-PAGE. Endotoxin: Biological Activity: Verified Protein construction: A DNA sequence encoding the human ADIPOQ (NP_001171271.1) (Met1-Asn244) was expressed with a polyhistidine tag at the C-terminus. NP No. NP_001171271.1 Expressing host: HEK293F Species: Human Glu 19 Molecular Weight: The recombinant human ADIPOQ consists of 237 amino acids and predicts a molecular mass of 26 kDa. Buffer solution: Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 8.0, 10 % glycerol.
Pleasecontact usfor any concerns or special requirements.
Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. Transportation method: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. stability & Storage: Samples are stable for up to twelve months from date of receipt at -20 to -80. Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Redissolution: A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer Adiponectin Protein, Human, Recombinant (His Tag): Alternative name : ACDC Protein, Human; ACRP30 Protein, Human; Adiponectin Protein, Human; ADIPQTL1 Protein, Human; ADPN Protein, Human; APM-1 Protein, Human; APM1 Protein, Human; GBP28 Protein, Human Adiponectin
Background Information : Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other tissues. Adiponectin mediates its actions in the periphery mainly via two receptors, AdipoR1 and AdipoR2. Adiponectin influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes. Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of Adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles. Unlike other adipocytokines produced by adipose tissue, Adiponectin appears to have anti-inflammatory, anti-diabetic, and anti-atherogenic properties. Several clinical studies demonstrate the inverse relationship between plasma Adiponectin levels and several inflammatory markers including C-reactive protein. Adiponectin attenuates inflammatory responses to multiple stimuli by modulating signaling pathways in a variety of cell types. The anti-inflammatory properties of Adiponectin may be a major component of its beneficial effects on cardiovascular and metabolic disorders including atherosclerosis and insulin resistance. Additionally, it is important factor in chronic liver diseases and chronic kidney diseases. Some cancer cell types express Adiponectin receptors. Thus Adiponectin may act on tumour cells directly by binding and activating Adiponectin receptors and downstream signalling pathways. Full Name: Adiponectin, C1Q and collagen domain containingMedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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