Species: Human Expressing host: E. coli Description: Recombinant Human GDNF Protein is produced by Escherichia coli expression system. The target protein is expressed with sequence of Human GDNF fused with polyhistidine tag at the C-terminus Tag: C-His Purity: > 95% by SDS-PAGE. Endotoxin: Biological Activity: Measured by its ability to inhibit proliferation in SH-SY5Y cells. The ED50for this effect is preparation: Lyophilized from a 0.22 m filtered solution of 20 mM sodium citrate, 0.2 M NaCl, pH 3.5. Storage Store the lyophilized protein at -20C to -80C for long term.
After reconstitution, the protein solution is stable at -20C for 3 months, at 2-8C for up to 1 week.Unopened freeze-dried powder,Store at -20 to -80 °C for twelve months
Redissolution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.Redissolution:Store at -20 to -80 °C,avoid repeated freeze thaw cycles
Background Information : Glial cell-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. GDNF, that acts via classical neurotrophic mechanism, has been effective in several pre-clinical models of PD and had some efficacy in parkinsonian patients. GeneID 2668 Swiss Prot P39905 Alias: GDNF;ATF;ATF1;ATF2;HFB1-GDNF;HSCR3MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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