Species: Human Expressing host: E. coli Description: Recombinant Human CCL18/PARC Protein is produced byE. coliexpression system. The target protein is expressed with sequence (Ala21-Ala89) of human CCL18/PARC (Accession #P55774) fused with an initial Met at the N-terminus and a 6His tag at the N-terminus. Tag: N-His Purity: > 95% by SDS-PAGE. Endotoxin: preparation: Lyophilized from a 0.2 m filtered solution of 20mM PB,150mM NaCl,pH7.4.Contact us for customized product form or formulation. Storage Store the lyophilized protein at -20C to -80 C for long term.
After reconstitution, the protein solution is stable at -20 C for 3 months, at 2-8 C for up to 1 week.Unopened freeze-dried powder,Store at -20 to -80 °C for twelve months
Redissolution: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.Redissolution:Store at -20 to -80 °C,avoid repeated freeze thaw cycles
Background Information : C-C Motif Chemokine 18 (CCL18) is secreted protein that belongs to the intercrine beta (chemokine CC) family.CCL18 is expressed at high levels in the lung, lymph nodes, placenta, bone marrow, and dendritic cells. CCL18 isa chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. CCL18 is a novel CCchemokine that is highly homologous to MIP-1 alpha. CCL18 may be involved in B-cell migration into B-cellfollicles in lymph nodes. CCL18 attracts naive T-lymphocytes toward dendritic cells and activated macrophagesin lymph nodes. It has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role inboth humoral and cell-mediated immunity responses. GeneID 6362 Swiss Prot P55774 Alias: CCL18;AMAC-1;AMAC1;CKb7;DC-CK1;DCCK1;MIP-4;PARC;SCYA18; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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