Species: Human Expressing host: HEK293 Description: Recombinant human IGF-II Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala25-Glu95) of human IGF-II (Accession #) fused with addtional amino acid free. Tag: No tag Purity: > 95% by Tris-Bis PAGE;> 95% by SEC-HPLC Endotoxin: preparation: 0.22 m filtered solution of PBS, pH 7.4. Storage Aliquot and store at -80C. Avoid repeated freeze/thaw cycles.Unopened freeze-dried powder,Store at -20 to -80 °C for twelve months
Redissolution: 0.2 mg/mL in sterile PBS, pH7.4Redissolution:Store at -20 to -80 °C,avoid repeated freeze thaw cycles
Background Information : Insulin-like growth factor I (also known as somatomedin C and somatomedin A) and insulin-like growth factor II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved (100% identity between human, bovine and porcine proteins) and exhibit cross-species activity.IGF-II is a potent mitogenic growth factor. However, unlike IGF-I which has important postnatal roles, the growth-promoting function of IGF-II is limited to embryonic development.Two specific cell surface receptors that bind IGF-I and IGF-II have been identified. The type I IGF receptor that participates in IGF signaling is structurally related to the insulin receptor. It is a disulfide-linked heterotetrameric transmembrane glycoprotein with an intracellular tyrosine kinase domain. Type I IGF receptor binds IGF-I with higher affinity than IGF-II. The type II IGF receptor which binds IGF-II with much higher affinity than IGF-I is also the cation-independent mannose 6-phosphate receptor. At the present time, it is not known if the type II IGF receptor participates in the IGF signaling pathway. An additional unknown receptor which mediates IGF?II signaling has also been proposed. Circulating IGFs exist in complexes bound to IGF binding proteins. Currently, at least six high affinity binding proteins have been identified. GeneID 3481 Swiss Prot P01344 Alias: IGF2;C11orf43;GRDF;IGF-II;PP9974MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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